Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.

Wahlberg, Elisabet; Karlberg, Tobias; Kouznetsova, Ekaterina; Markova, Natalia; Macchiarulo, Antonio; Thorsell, Ann-Gerd; Pol, Ewa; Frostell, Åsa; Ekblad, Torun; Öncü, Delal; Kull, Björn; Robertson, Graeme Michael; Pellicciari, Roberto; Schüler, Herwig; Weigelt, Johan

Wahlberg, Elisabet; Karlberg, Tobias; Kouznetsova, Ekaterina; Markova, Natalia; Macchiarulo, Antonio; Thorsell, Ann-Gerd; Pol, Ewa; Frostell, Åsa; Ekblad, Torun; Öncü, Delal; Kull, Björn; Robertson, Graeme Michael; Pellicciari, Roberto; Schüler, Herwig; Weigelt, Johan.

Affiliation

Wahlberg E; Structural Genomics Consortium, Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Stockholm, Sweden.

Nat Biotechnol ; 30(3): 283-8, 2012 Feb 19.

Article in En | MEDLINE | ID: mdl-22343925

Subject(s)

Enzyme Inhibitors/chemistry; Poly(ADP-ribose) Polymerase Inhibitors; Tankyrases/antagonists & inhibitors; Amino Acid Sequence; Binding Sites; Catalytic Domain/drug effects; Computer Simulation; Crystallography, X-Ray; Enzyme Inhibitors/pharmacology; Humans; Poly(ADP-ribose) Polymerases/metabolism; Protein Structure, Tertiary; Small Molecule Libraries/chemistry; Small Molecule Libraries/pharmacology; Tankyrases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tankyrases / Enzyme Inhibitors / Poly(ADP-ribose) Polymerase Inhibitors Limits: Humans Language: En Journal: Nat Biotechnol Journal subject: BIOTECNOLOGIA Year: 2012 Type: Article Affiliation country: Sweden

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