The protein phosphatase PP2A/B&#945; binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.

Sontag, Jean-Marie; Nunbhakdi-Craig, Viyada; White, Charles L; Halpain, Shelley; Sontag, Estelle

The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.

Sontag, Jean-Marie; Nunbhakdi-Craig, Viyada; White, Charles L; Halpain, Shelley; Sontag, Estelle.

Affiliation

Sontag JM; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales 2308, Australia.

J Biol Chem ; 287(18): 14984-93, 2012 Apr 27.

Article in En | MEDLINE | ID: mdl-22403409

Subject(s)

Alzheimer Disease/metabolism; Microtubule-Associated Proteins/metabolism; Nerve Tissue Proteins/metabolism; Neurons/metabolism; Protein Phosphatase 2/metabolism; Proto-Oncogene Proteins c-fyn/metabolism; tau Proteins/metabolism; Alzheimer Disease/pathology; Amino Acid Motifs; Animals; Cattle; Cell Line; Neurons/pathology; Peptides/pharmacology; Protein Binding/drug effects; Protein Isoforms/metabolism; Signal Transduction/drug effects

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tau Proteins / Proto-Oncogene Proteins c-fyn / Protein Phosphatase 2 / Alzheimer Disease / Microtubule-Associated Proteins / Nerve Tissue Proteins / Neurons Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: Australia

Fulltext

XML

PubMed Links

Search on Google