Cost-effectiveness analysis of FET PET-guided target selection for the diagnosis of gliomas.
Eur J Nucl Med Mol Imaging
; 39(7): 1089-96, 2012 Jul.
Article
in En
| MEDLINE
| ID: mdl-22419257
ABSTRACT
PURPOSE:
Several diagnostic trials have indicated that the combined use of (18)F-fluoroethyl-L -tyrosine (FET) PET and MRI may be superior to MRI alone in selecting the biopsy site for the diagnosis of gliomas. We estimated the cost-effectiveness of the use of amino acid PET compared to MRI alone from the perspective of the German statutory health insurance.METHODS:
To evaluate the incremental cost-effectiveness of the use of amino acid PET, a decision tree model was built. The effectiveness of FET PET was determined by the probability of a correct diagnosis. Costs were estimated for a baseline scenario and for a more expensive scenario in which disease severity was considered. The robustness of the results was tested using deterministic and probabilistic sensitivity analyses.RESULTS:
The combined use of PET and MRI resulted in an increase of 18.5% in the likelihood of a correct diagnosis. The incremental cost-effectiveness ratio for one additional correct diagnosis using FET PET was 6,405 for the baseline scenario and 9,114 for the scenario based on higher disease severity. The probabilistic sensitivity analysis confirmed the robustness of the results.CONCLUSION:
The model indicates that the use of amino acid PET may be cost-effective in patients with glioma. As a result of several limitations in the data used for the model, further studies are needed to confirm the results.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tyrosine
/
Brain Neoplasms
/
Radiopharmaceuticals
/
Positron-Emission Tomography
/
Glioma
Type of study:
Diagnostic_studies
/
Health_economic_evaluation
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Eur J Nucl Med Mol Imaging
Journal subject:
MEDICINA NUCLEAR
Year:
2012
Type:
Article
Affiliation country:
Germany