Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.

Bhutani, Nidhi; Piccirillo, Rosanna; Hourez, Raphael; Venkatraman, Prasanna; Goldberg, Alfred L

Bhutani, Nidhi; Piccirillo, Rosanna; Hourez, Raphael; Venkatraman, Prasanna; Goldberg, Alfred L.

Affiliation

Bhutani N; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.
Piccirillo R; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.
Hourez R; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.
Venkatraman P; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.
Goldberg AL; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115. Electronic address: alfred_goldberg@hms.harvard.edu.

J Biol Chem ; 287(21): 17471-17482, 2012 May 18.

Article in En | MEDLINE | ID: mdl-22451661

Subject(s)

Cathepsin L/metabolism; Cathepsin Z/metabolism; Lysosomes/metabolism; Peptides/metabolism; Animals; Cathepsin L/genetics; Cathepsin L/immunology; Cathepsin Z/genetics; Cathepsin Z/immunology; HEK293 Cells; HeLa Cells; Humans; Lysosomes/genetics; Lysosomes/immunology; Mice; Muscle, Skeletal/immunology; Muscle, Skeletal/metabolism; NIH 3T3 Cells; Neurodegenerative Diseases/genetics; Neurodegenerative Diseases/immunology; Neurodegenerative Diseases/metabolism; Peptides/genetics; Peptides/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Cathepsin L / Cathepsin Z / Lysosomes Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2012 Type: Article

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