Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury.

Deng, Wang; Li, Chang-Yi; Tong, Jin; Zhang, Wei; Wang, Dao-Xin

Deng, Wang; Li, Chang-Yi; Tong, Jin; Zhang, Wei; Wang, Dao-Xin.

Affiliation

Deng W; Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, China.

Respir Res ; 13: 29, 2012 Mar 30.

Article in En | MEDLINE | ID: mdl-22458687

Subject(s)

Acute Lung Injury/metabolism; Epithelial Sodium Channels/metabolism; Insulin/pharmacology; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Pulmonary Alveoli/metabolism; Signal Transduction/drug effects; Acute Lung Injury/chemically induced; Acute Lung Injury/pathology; Animals; Blood Glucose/metabolism; Cells, Cultured; Endosomal Sorting Complexes Required for Transport/metabolism; In Vitro Techniques; Insulin/blood; Interleukin-6/metabolism; Lipopolysaccharides/adverse effects; Male; Models, Animal; Nedd4 Ubiquitin Protein Ligases; Peroxidase/metabolism; Pulmonary Alveoli/pathology; Rats; Rats, Sprague-Dawley; Signal Transduction/physiology; Tumor Necrosis Factor-alpha/metabolism; Ubiquitin-Protein Ligases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Alveoli / Signal Transduction / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Epithelial Sodium Channels / Acute Lung Injury / Insulin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Respir Res Year: 2012 Type: Article Affiliation country: China

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