15-deoxy-&#916;¹²,¹4 -prostaglandin J2 inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-activated receptor-Î³ and heme oxygenase-1 in rat hippocampal slices.

Kim, Sang Eun; Lee, Eun Ok; Yang, Ji Hye; Kang, Ji Hee Lee; Suh, Yoo-Hun; Chong, Young Hae

15-deoxy-Δ¹²,¹4 -prostaglandin J2 inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-activated receptor-Î³ and heme oxygenase-1 in rat hippocampal slices.

Kim, Sang Eun; Lee, Eun Ok; Yang, Ji Hye; Kang, Ji Hee Lee; Suh, Yoo-Hun; Chong, Young Hae.

Affiliation

Kim SE; Department of Microbiology, School of Medicine, Ewha Medical Research Institute, Ewha Womans University, Seoul, Republic of Korea.

J Neurosci Res ; 90(9): 1732-42, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22487967

Subject(s)

Anti-Inflammatory Agents; Hippocampus; MAP Kinase Signaling System; Prostaglandin D2; Animals; Rats; Anti-Inflammatory Agents/pharmacology; Blotting, Western; Cell Differentiation/drug effects; Chemokine CCL2/metabolism; Enzyme-Linked Immunosorbent Assay; Heme Oxygenase-1/metabolism; Hippocampus/drug effects; Hippocampus/immunology; Hippocampus/pathology; HIV-1/immunology; MAP Kinase Signaling System/drug effects; MAP Kinase Signaling System/physiology; Microglia/cytology; Microglia/drug effects; PPAR gamma/metabolism; Prostaglandin D2/analogs & derivatives; Prostaglandin D2/pharmacology; tat Gene Products, Human Immunodeficiency Virus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostaglandin D2 / MAP Kinase Signaling System / Hippocampus / Anti-Inflammatory Agents Limits: Animals Language: En Journal: J Neurosci Res Year: 2012 Type: Article

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