Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects.

Osada, Takuya; Berglund, Peter; Morse, Michael A; Hubby, Bolyn; Lewis, Whitney; Niedzwiecki, Donna; Yang, Xiao Yi; Hobeika, Amy; Burnett, Bruce; Devi, Gayathri R; Clay, Timothy M; Smith, Jonathan; Kim Lyerly, H

Osada, Takuya; Berglund, Peter; Morse, Michael A; Hubby, Bolyn; Lewis, Whitney; Niedzwiecki, Donna; Yang, Xiao Yi; Hobeika, Amy; Burnett, Bruce; Devi, Gayathri R; Clay, Timothy M; Smith, Jonathan; Kim Lyerly, H.

Affiliation

Osada T; Department of Surgery, Duke University Medical Center, Box 2606 MSRB1 Rm 433b Research Dr, Durham, NC 27710, USA.

Cancer Immunol Immunother ; 61(11): 1941-51, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22488274

Subject(s)

Cancer Vaccines/therapeutic use; Carcinoembryonic Antigen/immunology; Colonic Neoplasms/therapy; Encephalitis Virus, Venezuelan Equine; Interleukin-12/immunology; Adjuvants, Immunologic; Animals; Antibodies, Neoplasm/blood; Antibodies, Neoplasm/immunology; Cancer Vaccines/genetics; Cancer Vaccines/immunology; Carcinoembryonic Antigen/genetics; Cell Line, Tumor; Humans; Interleukin-12/genetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Replicon; T-Lymphocytes/immunology; Virion

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoembryonic Antigen / Colonic Neoplasms / Interleukin-12 / Cancer Vaccines / Encephalitis Virus, Venezuelan Equine Limits: Animals / Humans Country/Region as subject: America do sul / Venezuela Language: En Journal: Cancer Immunol Immunother Journal subject: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Year: 2012 Type: Article Affiliation country: United States

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