Combining doublecortin-like kinase silencing and vinca alkaloids results in a synergistic apoptotic effect in neuroblastoma cells.

Verissimo, Carla S; Cheng, Sou; Puigvert, Jordi C; Qin, Yu; Vroon, Anne; van Deutekom, Judith; Price, Leo S; Danen, Erik H J; van de Water, Bob; Fitzsimons, Carlos P; Vreugdenhil, Erno

Verissimo, Carla S; Cheng, Sou; Puigvert, Jordi C; Qin, Yu; Vroon, Anne; van Deutekom, Judith; Price, Leo S; Danen, Erik H J; van de Water, Bob; Fitzsimons, Carlos P; Vreugdenhil, Erno.

Affiliation

Verissimo CS; Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden, The Netherlands.

J Pharmacol Exp Ther ; 342(1): 119-30, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22490379

Subject(s)

Apoptosis/drug effects; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Neuroblastoma/drug therapy; Protein Serine-Threonine Kinases/antagonists & inhibitors; Vinca Alkaloids/pharmacology; Animals; Apoptosis/genetics; Caspase 3/genetics; Caspase 3/metabolism; Caspase 8/genetics; Caspase 8/metabolism; Cell Death/drug effects; Cell Death/genetics; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Cell Survival/genetics; Doublecortin-Like Kinases; Drug Synergism; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Mice; Microtubule-Associated Proteins/genetics; Microtubule-Associated Proteins/metabolism; Microtubules/drug effects; Microtubules/genetics; Microtubules/metabolism; Mitochondria/drug effects; Mitochondria/genetics; Mitochondria/metabolism; Neuroblastoma/genetics; Neuroblastoma/metabolism; Neuroblastoma/pathology; Phosphatidylserines/genetics; Phosphatidylserines/metabolism; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Protein Transport/drug effects; Protein Transport/genetics; Vinblastine/pharmacology; Vincristine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vinca Alkaloids / Protein Serine-Threonine Kinases / Apoptosis / Intracellular Signaling Peptides and Proteins / Neuroblastoma Language: En Journal: J Pharmacol Exp Ther Year: 2012 Type: Article Affiliation country: Netherlands

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