Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.

Charrier, Cécile; Joshi, Kaumudi; Coutinho-Budd, Jaeda; Kim, Ji-Eun; Lambert, Nelle; de Marchena, Jacqueline; Jin, Wei-Lin; Vanderhaeghen, Pierre; Ghosh, Anirvan; Sassa, Takayuki; Polleux, Franck

Charrier, Cécile; Joshi, Kaumudi; Coutinho-Budd, Jaeda; Kim, Ji-Eun; Lambert, Nelle; de Marchena, Jacqueline; Jin, Wei-Lin; Vanderhaeghen, Pierre; Ghosh, Anirvan; Sassa, Takayuki; Polleux, Franck.

Affiliation

Charrier C; Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

Cell ; 149(4): 923-35, 2012 May 11.

Article in En | MEDLINE | ID: mdl-22559944

Subject(s)

Brain/cytology; Brain/embryology; GTPase-Activating Proteins/genetics; Gene Duplication; Neurons/cytology; Segmental Duplications, Genomic; Animals; Cell Movement; Dendritic Spines/metabolism; Evolution, Molecular; Humans; Mice; Molecular Sequence Data; Neurons/metabolism; Protein Structure, Tertiary; Species Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Gene Duplication / GTPase-Activating Proteins / Segmental Duplications, Genomic / Neurons Limits: Animals / Humans Language: En Journal: Cell Year: 2012 Type: Article Affiliation country: United States

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