Nicotine and lipopolysaccharide stimulate the production of MMPs and prostaglandin E2 by hypoxia-inducible factor-1&#945; up-regulation in human periodontal ligament cells.

Kim, Y-S; Shin, S-I; Kang, K-L; Chung, J-H; Herr, Y; Bae, W-J; Kim, E-C

Nicotine and lipopolysaccharide stimulate the production of MMPs and prostaglandin E2 by hypoxia-inducible factor-1α up-regulation in human periodontal ligament cells.

Kim, Y-S; Shin, S-I; Kang, K-L; Chung, J-H; Herr, Y; Bae, W-J; Kim, E-C.

Affiliation

Kim YS; Department of Maxillofacial Tissue Regeneration, School of Dentistry and Institute of Oral Biology, Seoul, Korea.

J Periodontal Res ; 47(6): 719-28, 2012 Dec.

Article in En | MEDLINE | ID: mdl-22571166

Subject(s)

Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Lipopolysaccharides/pharmacology; Nicotine/pharmacology; Periodontal Ligament/cytology; Periodontal Ligament/drug effects; Analysis of Variance; Cell Line, Transformed; Cyclooxygenase 2/biosynthesis; Dinoprostone/biosynthesis; Drug Synergism; Extracellular Signal-Regulated MAP Kinases/physiology; Fibroblasts/drug effects; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 2/biosynthesis; Matrix Metalloproteinase 9/biosynthesis; Periodontal Ligament/metabolism; Porphyromonas gingivalis/chemistry; Statistics, Nonparametric; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Periodontal Ligament / Lipopolysaccharides / Hypoxia-Inducible Factor 1, alpha Subunit / Nicotine Limits: Humans Language: En Journal: J Periodontal Res Year: 2012 Type: Article

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