Epstein-Barr virus infection of naïve B cells in vitro frequently selects clones with mutated immunoglobulin genotypes: implications for virus biology.

Heath, Emily; Begue-Pastor, Noelia; Chaganti, Sridhar; Croom-Carter, Debbie; Shannon-Lowe, Claire; Kube, Dieter; Feederle, Regina; Delecluse, Henri-Jacques; Rickinson, Alan B; Bell, Andrew I

Heath, Emily; Begue-Pastor, Noelia; Chaganti, Sridhar; Croom-Carter, Debbie; Shannon-Lowe, Claire; Kube, Dieter; Feederle, Regina; Delecluse, Henri-Jacques; Rickinson, Alan B; Bell, Andrew I.

Affiliation

Heath E; School of Cancer Sciences, College of Medicine and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

PLoS Pathog ; 8(5): e1002697, 2012.

Article in En | MEDLINE | ID: mdl-22589726

Subject(s)

B-Lymphocyte Subsets/immunology; B-Lymphocyte Subsets/virology; Genes, Immunoglobulin; Herpesvirus 4, Human/immunology; Herpesvirus 4, Human/physiology; Immunoglobulin Class Switching; Cells, Cultured; Cytidine Deaminase/biosynthesis; Epstein-Barr Virus Infections/immunology; Genotype; Herpesvirus 4, Human/pathogenicity; Humans; Immunoglobulin D/genetics; Immunoglobulin Heavy Chains/genetics; Immunoglobulin M/genetics; Immunologic Memory/immunology; Mutation; Somatic Hypermutation, Immunoglobulin; Tumor Necrosis Factor Receptor Superfamily, Member 7/biosynthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genes, Immunoglobulin / B-Lymphocyte Subsets / Immunoglobulin Class Switching / Herpesvirus 4, Human Limits: Humans Language: En Journal: PLoS Pathog Year: 2012 Type: Article Affiliation country: United kingdom

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