Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression.

Selamat, Suhaida A; Chung, Brian S; Girard, Luc; Zhang, Wei; Zhang, Ying; Campan, Mihaela; Siegmund, Kimberly D; Koss, Michael N; Hagen, Jeffrey A; Lam, Wan L; Lam, Stephen; Gazdar, Adi F; Laird-Offringa, Ite A

Selamat, Suhaida A; Chung, Brian S; Girard, Luc; Zhang, Wei; Zhang, Ying; Campan, Mihaela; Siegmund, Kimberly D; Koss, Michael N; Hagen, Jeffrey A; Lam, Wan L; Lam, Stephen; Gazdar, Adi F; Laird-Offringa, Ite A.

Affiliation

Selamat SA; Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176, USA.

Genome Res ; 22(7): 1197-211, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22613842

Subject(s)

Adenocarcinoma/genetics; DNA Methylation; Gene Expression Profiling/methods; Gene Expression Regulation, Neoplastic; Lung Neoplasms/genetics; RNA, Messenger/metabolism; Adenocarcinoma/metabolism; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Case-Control Studies; Cell Differentiation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Female; Galectin 4/genetics; Galectin 4/metabolism; Genes, Neoplasm; Genome, Human; Humans; Lung/metabolism; Lung/pathology; Lung Neoplasms/metabolism; Male; Middle Aged; Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins p21(ras); RNA, Messenger/genetics; Smoking/genetics; Smoking/pathology; Wnt Signaling Pathway; ras Proteins/genetics; ras Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Adenocarcinoma / Gene Expression Regulation, Neoplastic / DNA Methylation / Gene Expression Profiling / Lung Neoplasms Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged80 Language: En Journal: Genome Res Journal subject: BIOLOGIA MOLECULAR / GENETICA Year: 2012 Type: Article Affiliation country: United States

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