Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E.

Ge, Yuqing; Cheng, Rubin; Zhou, Yuhong; Shen, Jianping; Peng, Laijun; Xu, Xiaofeng; Dai, Qun; Liu, Pei; Wang, Haibing; Ma, Xiaoqiong; Jia, Jia; Chen, Zhe

Ge, Yuqing; Cheng, Rubin; Zhou, Yuhong; Shen, Jianping; Peng, Laijun; Xu, Xiaofeng; Dai, Qun; Liu, Pei; Wang, Haibing; Ma, Xiaoqiong; Jia, Jia; Chen, Zhe.

Affiliation

Ge Y; Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Hangzhou 310006, China.

Mol Cell Biochem ; 368(1-2): 17-25, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22614784

Subject(s)

Apoptosis/drug effects; Cell Cycle Checkpoints/drug effects; Drug Resistance, Multiple/drug effects; Drug Resistance, Neoplasm/drug effects; Eukaryotic Initiation Factor-4E/metabolism; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism; Peptide Chain Initiation, Translational/drug effects; Phenanthrenes/pharmacology; Apoptosis/genetics; Cell Cycle Checkpoints/genetics; Cyclin D1/genetics; Cyclin D1/metabolism; Drug Resistance, Multiple/genetics; Drug Resistance, Neoplasm/genetics; Eukaryotic Initiation Factor-4E/genetics; Gene Expression Regulation, Leukemic/drug effects; Gene Expression Regulation, Leukemic/genetics; Gene Knockdown Techniques; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics; Peptide Chain Initiation, Translational/genetics; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Chain Initiation, Translational / Phenanthrenes / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Apoptosis / Drug Resistance, Multiple / Drug Resistance, Neoplasm / Eukaryotic Initiation Factor-4E / Cell Cycle Checkpoints Limits: Humans Language: En Journal: Mol Cell Biochem Year: 2012 Type: Article Affiliation country: China

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