Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.

Szabova, Ludmila; Yin, Chaoying; Bupp, Sujata; Guerin, Theresa M; Schlomer, Jerome J; Householder, Deborah B; Baran, Maureen L; Yi, Ming; Song, Yurong; Sun, Wenping; McDunn, Jonathan E; Martin, Philip L; Van Dyke, Terry; Difilippantonio, Simone

Szabova, Ludmila; Yin, Chaoying; Bupp, Sujata; Guerin, Theresa M; Schlomer, Jerome J; Householder, Deborah B; Baran, Maureen L; Yi, Ming; Song, Yurong; Sun, Wenping; McDunn, Jonathan E; Martin, Philip L; Van Dyke, Terry; Difilippantonio, Simone.

Affiliation

Szabova L; Center for Advanced Preclinical Research, Advanced Biomedical Computing Center, SAIC at Frederick National Laboratory for Cancer Research, Mouse Cancer Genetics Program, NCI-Frederick, Frederick, Maryland 21702, USA.

Cancer Res ; 72(16): 4141-53, 2012 Aug 15.

Article in En | MEDLINE | ID: mdl-22617326

Subject(s)

BRCA1 Protein/metabolism; BRCA2 Protein/metabolism; Neoplasms, Glandular and Epithelial/metabolism; Neoplasms, Glandular and Epithelial/pathology; Ovarian Neoplasms/metabolism; Ovarian Neoplasms/pathology; Retinoblastoma Protein/metabolism; Tumor Suppressor Protein p53/metabolism; Animals; BRCA1 Protein/genetics; BRCA2 Protein/genetics; Carcinoma, Ovarian Epithelial; Disease Models, Animal; Female; Gene Deletion; Immunohistochemistry; Mice; Mice, Transgenic; Mutation; Neoplasm Metastasis; Neoplasms, Glandular and Epithelial/genetics; Ovarian Neoplasms/genetics; Tumor Suppressor Protein p53/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Tumor Suppressor Protein p53 / Retinoblastoma Protein / Neoplasms, Glandular and Epithelial / BRCA1 Protein / BRCA2 Protein Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cancer Res Year: 2012 Type: Article Affiliation country: United States

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