The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice.

Richards, M Rachel; Black, Audrey S; Bonnet, David J; Barish, Grant D; Woo, Connie W; Tabas, Ira; Curtiss, Linda K; Tobias, Peter S

Richards, M Rachel; Black, Audrey S; Bonnet, David J; Barish, Grant D; Woo, Connie W; Tabas, Ira; Curtiss, Linda K; Tobias, Peter S.

Affiliation

Richards MR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

Innate Immun ; 19(1): 20-9, 2013 Feb.

Article in En | MEDLINE | ID: mdl-22637968

Subject(s)

Adaptor Proteins, Vesicular Transport/metabolism; Atherosclerosis/genetics; Hyperlipidemias/genetics; Lipoproteins, LDL/metabolism; Toll-Like Receptor 3/metabolism; Adaptor Proteins, Vesicular Transport/genetics; Animals; Aorta/pathology; Atherosclerosis/etiology; Atherosclerosis/pathology; Atherosclerosis/prevention & control; Coronary Vessels/pathology; Cytokines/immunology; Diet, Atherogenic; Hyperlipidemias/complications; Hyperlipidemias/pathology; Lipoproteins, LDL/genetics; Macrophages, Peritoneal/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Mutation/genetics; Myeloid Differentiation Factor 88/metabolism; Signal Transduction/genetics; Toll-Like Receptor 3/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adaptor Proteins, Vesicular Transport / Atherosclerosis / Toll-Like Receptor 3 / Hyperlipidemias / Lipoproteins, LDL Type of study: Etiology_studies Limits: Animals Language: En Journal: Innate Immun Journal subject: ALERGIA E IMUNOLOGIA / BACTERIOLOGIA Year: 2013 Type: Article Affiliation country: United States

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