p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.

Tomita, Kengo; Teratani, Toshiaki; Suzuki, Takahiro; Oshikawa, Tetsuya; Yokoyama, Hirokazu; Shimamura, Katsuyoshi; Nishiyama, Kiyoshi; Mataki, Norikazu; Irie, Rie; Minamino, Tohru; Okada, Yoshikiyo; Kurihara, Chie; Ebinuma, Hirotoshi; Saito, Hidetsugu; Shimizu, Ippei; Yoshida, Yohko; Hokari, Ryota; Sugiyama, Kazuo; Hatsuse, Kazuo; Yamamoto, Junji; Kanai, Takanori; Miura, Soichiro; Hibi, Toshifumi

Tomita, Kengo; Teratani, Toshiaki; Suzuki, Takahiro; Oshikawa, Tetsuya; Yokoyama, Hirokazu; Shimamura, Katsuyoshi; Nishiyama, Kiyoshi; Mataki, Norikazu; Irie, Rie; Minamino, Tohru; Okada, Yoshikiyo; Kurihara, Chie; Ebinuma, Hirotoshi; Saito, Hidetsugu; Shimizu, Ippei; Yoshida, Yohko; Hokari, Ryota; Sugiyama, Kazuo; Hatsuse, Kazuo; Yamamoto, Junji; Kanai, Takanori; Miura, Soichiro; Hibi, Toshifumi.

Affiliation

Tomita K; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan. kengo@ndmc.ac.jp

J Hepatol ; 57(4): 837-43, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22641095

Subject(s)

Fatty Liver/metabolism; RNA, Messenger/metabolism; Shc Signaling Adaptor Proteins/metabolism; Tumor Suppressor Protein p53/metabolism; Animals; Apoptosis/drug effects; Caspase 3/metabolism; Choline Deficiency/complications; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Disease Models, Animal; Disease Progression; Fatty Liver/etiology; Fatty Liver/pathology; Hepatocytes/metabolism; Humans; Male; Methionine/deficiency; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Primary Cell Culture; Proto-Oncogene Proteins p21(ras)/metabolism; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Src Homology 2 Domain-Containing, Transforming Protein 1; Transforming Growth Factor beta/metabolism; Transforming Growth Factor beta/pharmacology; Tumor Suppressor Protein p53/genetics; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Tumor Suppressor Protein p53 / Shc Signaling Adaptor Proteins / Fatty Liver Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 2012 Type: Article Affiliation country: Japan

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