[Post-thymus transplant vitiligo in a child with Foxn1 deficiency]. / Vitiligo post-greffe thymique chez un enfant porteur d'un déficit en Foxn1.
Ann Dermatol Venereol
; 139(6-7): 468-71, 2012 Jun.
Article
in Fr
| MEDLINE
| ID: mdl-22721479
ABSTRACT
BACKGROUND:
Foxn1 transcription factor deficit leads to immune deficiency, with hair and nail abnormalities. We report the case of a patient also presenting localized leucoderma. CASE REPORT A 3-year-old boy underwent thymus transplantation at the age of 9 months for Foxn1 deficiency. He had developed urticaria and autoimmune hypothyroidism after thymus grafting. On examination, he had universal non-scarring alopecia, nail changes (atrophy, partial onycholysis and longitudinal grooves) and leucoderma on both big toes.DISCUSSION:
This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation. The pathogenic hypotheses discussed were post-graft vitiligo and leucoderma induced by Foxn1 deficiency.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Postoperative Complications
/
Thymus Gland
/
Vitiligo
/
Forkhead Transcription Factors
/
Immunologic Deficiency Syndromes
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Child, preschool
/
Humans
/
Infant
/
Male
Language:
Fr
Journal:
Ann Dermatol Venereol
Year:
2012
Type:
Article
Affiliation country:
France