Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain.

Bottiglieri, Teodoro; Arning, Erland; Wasek, Brandi; Nunbhakdi-Craig, Viyada; Sontag, Jean-Marie; Sontag, Estelle

Bottiglieri, Teodoro; Arning, Erland; Wasek, Brandi; Nunbhakdi-Craig, Viyada; Sontag, Jean-Marie; Sontag, Estelle.

Affiliation

Bottiglieri T; Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas 75226, USA. teodorob@baylorhealth.edu

J Neurosci ; 32(27): 9173-81, 2012 Jul 04.

Article in En | MEDLINE | ID: mdl-22764226

Subject(s)

Brain/metabolism; Dopaminergic Neurons/enzymology; Levodopa/toxicity; Nerve Degeneration/metabolism; Protein Phosphatase 2/metabolism; tau Proteins/metabolism; Animals; Antiparkinson Agents/toxicity; Brain/drug effects; Brain/pathology; Cell Line, Tumor; Dopaminergic Neurons/drug effects; Humans; Male; Methylation/drug effects; Mice; Mice, Inbred C57BL; Nerve Degeneration/chemically induced; Nerve Degeneration/physiopathology; Neuroblastoma; Phosphorylation/drug effects; Phosphorylation/physiology; Primary Cell Culture; Protein Phosphatase 2/antagonists & inhibitors; tau Proteins/agonists; tau Proteins/biosynthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Levodopa / Tau Proteins / Protein Phosphatase 2 / Dopaminergic Neurons / Nerve Degeneration Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Neurosci Year: 2012 Type: Article Affiliation country: United States

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