Beyond KRAS mutation status: influence of KRAS copy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients.

Mekenkamp, Leonie J M; Tol, Jolien; Dijkstra, Jeroen R; de Krijger, Inge; Vink-Börger, M Elisa; van Vliet, Shannon; Teerenstra, Steven; Kamping, Eveline; Verwiel, Eugène; Koopman, Miriam; Meijer, Gerrit A; van Krieken, J Han Jm; Kuiper, Roland; Punt, Cornelis J A; Nagtegaal, Iris D

Mekenkamp, Leonie J M; Tol, Jolien; Dijkstra, Jeroen R; de Krijger, Inge; Vink-Börger, M Elisa; van Vliet, Shannon; Teerenstra, Steven; Kamping, Eveline; Verwiel, Eugène; Koopman, Miriam; Meijer, Gerrit A; van Krieken, J Han Jm; Kuiper, Roland; Punt, Cornelis J A; Nagtegaal, Iris D.

Affiliation

Mekenkamp LJ; Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

BMC Cancer ; 12: 292, 2012 Jul 17.

Article in En | MEDLINE | ID: mdl-22804917

Subject(s)

Colorectal Neoplasms/genetics; DNA Copy Number Variations; MicroRNAs/genetics; Mutation; Proto-Oncogene Proteins/genetics; ras Proteins/genetics; Antibodies, Monoclonal/administration & dosage; Antibodies, Monoclonal, Humanized/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Bevacizumab; Cetuximab; Chromosomes, Human, Pair 12/genetics; Clinical Trials, Phase III as Topic; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/pathology; Disease-Free Survival; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Neoplasm Metastasis; Organoplatinum Compounds/administration & dosage; Oxaliplatin; Proto-Oncogene Proteins p21(ras); Randomized Controlled Trials as Topic; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Proto-Oncogene Proteins / Ras Proteins / MicroRNAs / DNA Copy Number Variations / Mutation Type of study: Clinical_trials / Prognostic_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2012 Type: Article Affiliation country: Netherlands

Fulltext

XML

PubMed Links

Search on Google