Pharmacology of somatrotropin pegylated by electron-beam synthesis nanotechnology.

Dygai, A M; Zyuz'kov, G N; Churin, A A; Zhdanov, V V; Artamonov, A V; Bekarev, A A; Madonov, P G; Kinsht, D N; Fomina, T I; Vetoshkina, T V; Dubskaia, T Yu; Ermolaeva, L A; Udut, E V; Miroshnichenko, L A; Simanina, E V; Stavrova, L A; Chaikovskiy, A V; Markova, T S; Minakova, M Yu; Reihart, D V

Dygai, A M; Zyuz'kov, G N; Churin, A A; Zhdanov, V V; Artamonov, A V; Bekarev, A A; Madonov, P G; Kinsht, D N; Fomina, T I; Vetoshkina, T V; Dubskaia, T Yu; Ermolaeva, L A; Udut, E V; Miroshnichenko, L A; Simanina, E V; Stavrova, L A; Chaikovskiy, A V; Markova, T S; Minakova, M Yu; Reihart, D V.

Affiliation

Dygai AM; Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru

Bull Exp Biol Med ; 153(2): 263-5, 2012 Jun.

Article in En, Ru | MEDLINE | ID: mdl-22816098

ABSTRACT

ABSTRACT

Pharmacological characteristics of somatotropin pegylated using electron-beam synthesis nanotechnology (PEG-STH) were studied. Oral PEG-STH stimulated the intensity of protein and lipid metabolism and endochondral bone growth without modifying the processes of periosteal and endosteal bone formation. Specific activity of this substance administered orally significantly surpassed that of parenteral non-modified growth hormone.

Subject(s)

Bone Development/drug effects; Human Growth Hormone/pharmacology; Lipid Metabolism/drug effects; Nanotechnology; Polyethylene Glycols; Proteins/metabolism; Animals; Male; Rats; Rats, Wistar

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Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Bone Development / Proteins / Human Growth Hormone / Nanotechnology / Lipid Metabolism Limits: Animals Language: En / Ru Journal: Bull Exp Biol Med Year: 2012 Type: Article Affiliation country: RUSSIA

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