CAG expansion induces nucleolar stress in polyglutamine diseases.

Tsoi, Ho; Lau, Terrence Chi-Kong; Tsang, Suk-Ying; Lau, Kwok-Fai; Chan, Ho Yin Edwin

Tsoi, Ho; Lau, Terrence Chi-Kong; Tsang, Suk-Ying; Lau, Kwok-Fai; Chan, Ho Yin Edwin.

Affiliation

Tsoi H; Laboratory of Drosophila Research, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.

Proc Natl Acad Sci U S A ; 109(33): 13428-33, 2012 Aug 14.

Article in En | MEDLINE | ID: mdl-22847428

Subject(s)

Cell Nucleolus/genetics; Neurodegenerative Diseases/genetics; Peptides/metabolism; Stress, Physiological/genetics; Trinucleotide Repeat Expansion/genetics; Animals; Caspases/metabolism; Cytochromes c/metabolism; DNA Methylation/genetics; Enzyme Activation; Humans; Mice; Mitochondria/genetics; Models, Biological; Phosphoproteins/metabolism; Promoter Regions, Genetic/genetics; Protein Binding; RNA Polymerase I/metabolism; RNA Stability/genetics; RNA, Ribosomal/genetics; RNA, Ribosomal/metabolism; RNA-Binding Proteins/metabolism; Transcription, Genetic; Tumor Suppressor Protein p53/metabolism; Nucleolin

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Stress, Physiological / Cell Nucleolus / Neurodegenerative Diseases / Trinucleotide Repeat Expansion Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2012 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google