Synergistic effect of panobinostat and bortezomib on chemoresistant acute myelogenous leukemia cells via AKT and NF-&#954;B pathways.

Jiang, Xue-Jie; Huang, Kai-Kai; Yang, Mo; Qiao, Liang; Wang, Qiang; Ye, Jie-Yu; Zhou, Hong-Sheng; Yi, Zheng-Shan; Wu, Fu-Qun; Wang, Zhi-Xiang; Zhao, Qing-Xia; Meng, Fan-Yi

Synergistic effect of panobinostat and bortezomib on chemoresistant acute myelogenous leukemia cells via AKT and NF-κB pathways.

Jiang, Xue-Jie; Huang, Kai-Kai; Yang, Mo; Qiao, Liang; Wang, Qiang; Ye, Jie-Yu; Zhou, Hong-Sheng; Yi, Zheng-Shan; Wu, Fu-Qun; Wang, Zhi-Xiang; Zhao, Qing-Xia; Meng, Fan-Yi.

Affiliation

Jiang XJ; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Cancer Lett ; 326(2): 135-42, 2012 Dec 30.

Article in En | MEDLINE | ID: mdl-22863538

Subject(s)

Antineoplastic Agents/therapeutic use; Boronic Acids/therapeutic use; Hydroxamic Acids/therapeutic use; Indoles/therapeutic use; Leukemia, Myeloid, Acute/drug therapy; NF-kappa B/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Pyrazines/therapeutic use; Acetylation; Antineoplastic Agents/pharmacology; Boronic Acids/pharmacology; Bortezomib; Caspases/metabolism; Drug Resistance, Neoplasm; Drug Synergism; HL-60 Cells; Humans; Hydroxamic Acids/pharmacology; Indoles/pharmacology; Leukemia, Myeloid, Acute/pathology; Panobinostat; Poly(ADP-ribose) Polymerases/metabolism; Proteolysis; Pyrazines/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Boronic Acids / Leukemia, Myeloid, Acute / NF-kappa B / Proto-Oncogene Proteins c-akt / Hydroxamic Acids / Indoles / Antineoplastic Agents Type of study: Guideline Limits: Humans Language: En Journal: Cancer Lett Year: 2012 Type: Article Affiliation country: China

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