Thioredoxin-interacting protein mediates ER stress-induced ß cell death through initiation of the inflammasome.

Oslowski, Christine M; Hara, Takashi; O'Sullivan-Murphy, Bryan; Kanekura, Kohsuke; Lu, Simin; Hara, Mariko; Ishigaki, Shinsuke; Zhu, Lihua J; Hayashi, Emiko; Hui, Simon T; Greiner, Dale; Kaufman, Randal J; Bortell, Rita; Urano, Fumihiko

Oslowski, Christine M; Hara, Takashi; O'Sullivan-Murphy, Bryan; Kanekura, Kohsuke; Lu, Simin; Hara, Mariko; Ishigaki, Shinsuke; Zhu, Lihua J; Hayashi, Emiko; Hui, Simon T; Greiner, Dale; Kaufman, Randal J; Bortell, Rita; Urano, Fumihiko.

Affiliation

Oslowski CM; Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Cell Metab ; 16(2): 265-73, 2012 Aug 08.

Article in En | MEDLINE | ID: mdl-22883234

Subject(s)

Apoptosis/physiology; Carrier Proteins/metabolism; Diabetes Mellitus/metabolism; Endoplasmic Reticulum Stress/physiology; Inflammasomes/metabolism; Insulin-Secreting Cells/physiology; Signal Transduction/physiology; Thioredoxins/metabolism; Animals; Carrier Proteins/genetics; Carrier Proteins/physiology; Cell Line; Chromatin Immunoprecipitation; Humans; Immunoblotting; Interleukin-1beta/metabolism; Luciferases; Membrane Proteins/metabolism; Mice; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Serine-Threonine Kinases/metabolism; Thioredoxins/genetics; Thioredoxins/physiology; eIF-2 Kinase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioredoxins / Signal Transduction / Carrier Proteins / Apoptosis / Diabetes Mellitus / Insulin-Secreting Cells / Inflammasomes / Endoplasmic Reticulum Stress Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2012 Type: Article Affiliation country: United States

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