A four-week repeated study of intravenous toxicity of recombinant human interleukin-2 in Sprague-Dawley rats.

Lee, Mi Ju; Park, Sun Hee; Kim, Myoung Jun; Kim, Hye-Jin; Li, Yinghua; Ko, Kyeoung-Nam; Kim, Duyeol; Lee, Yong-Hoon; Kim, Sun-Hee; Jang, Ho-Song; Baik, Yeongjun; Lee, Sunghee; Kang, Jin Seok; Kang, Jong-Koo

Lee, Mi Ju; Park, Sun Hee; Kim, Myoung Jun; Kim, Hye-Jin; Li, Yinghua; Ko, Kyeoung-Nam; Kim, Duyeol; Lee, Yong-Hoon; Kim, Sun-Hee; Jang, Ho-Song; Baik, Yeongjun; Lee, Sunghee; Kang, Jin Seok; Kang, Jong-Koo.

Affiliation

Lee MJ; Department of Pathology, Biotoxtech Co. Ltd., 686-2 Yangcheong-ri, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea.

Regul Toxicol Pharmacol ; 64(2): 253-62, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22885075

Subject(s)

Interleukin-2/toxicity; Administration, Intravenous; Animals; Drug Evaluation, Preclinical; Female; Humans; Interleukin-2/administration & dosage; Interleukin-2/pharmacokinetics; Male; No-Observed-Adverse-Effect Level; Rats; Rats, Sprague-Dawley; Recombinant Proteins/administration & dosage; Recombinant Proteins/pharmacokinetics; Recombinant Proteins/toxicity; Therapeutic Equivalency; Toxicity Tests, Subacute

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-2 Limits: Animals / Female / Humans / Male Language: En Journal: Regul Toxicol Pharmacol Year: 2012 Type: Article

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