The ability of phosphodiesterase-5 inhibitors sildenafil and ordonafil to reverse L-NAME induced cardiac hypertrophy in the rabbit: possible role of calcineurin and p38.

Zeidan, Asad; Siam, Aiad; Al Kaabba, Abdulaziz; Mohammad, Mukhallad; Khatib, Said

Zeidan, Asad; Siam, Aiad; Al Kaabba, Abdulaziz; Mohammad, Mukhallad; Khatib, Said.

Affiliation

Zeidan A; Department of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Lebanon.

Can J Physiol Pharmacol ; 90(9): 1247-55, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22913522

Subject(s)

Calcineurin/metabolism; Cardiomegaly/prevention & control; NG-Nitroarginine Methyl Ester/pharmacology; Phosphodiesterase 5 Inhibitors/pharmacology; Piperazines/pharmacology; Sulfones/pharmacology; p38 Mitogen-Activated Protein Kinases/metabolism; Animals; Cardiomegaly/chemically induced; Cardiomegaly/enzymology; Cardiomegaly/pathology; Cell Size/drug effects; Female; Male; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/enzymology; Myocytes, Cardiac/pathology; Phosphodiesterase 5 Inhibitors/therapeutic use; Piperazines/therapeutic use; Purines/pharmacology; Purines/therapeutic use; Rabbits; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Sulfones / Cardiomegaly / NG-Nitroarginine Methyl Ester / Calcineurin / P38 Mitogen-Activated Protein Kinases / Phosphodiesterase 5 Inhibitors Limits: Animals Language: En Journal: Can J Physiol Pharmacol Year: 2012 Type: Article Affiliation country: Lebanon

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