Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.

Hashimoto, Hideharu; Hong, Samuel; Bhagwat, Ashok S; Zhang, Xing; Cheng, Xiaodong

Hashimoto, Hideharu; Hong, Samuel; Bhagwat, Ashok S; Zhang, Xing; Cheng, Xiaodong.

Affiliation

Hashimoto H; Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA.

Nucleic Acids Res ; 40(20): 10203-14, 2012 Nov 01.

Article in En | MEDLINE | ID: mdl-22962365

Subject(s)

Cytosine/analogs & derivatives; DNA/chemistry; Pentoxyl/analogs & derivatives; Thymine DNA Glycosylase/chemistry; Biocatalysis; Catalytic Domain; Cytosine/chemistry; Cytosine/metabolism; DNA/metabolism; Humans; Models, Molecular; Pentoxyl/chemistry; Pentoxyl/metabolism; Thymine DNA Glycosylase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pentoxyl / DNA / Cytosine / Thymine DNA Glycosylase Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2012 Type: Article Affiliation country: United States

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