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TLR 2 induces vascular smooth muscle cell migration through cAMP response element-binding protein-mediated interleukin-6 production.
Lee, Guan-Lin; Chang, Ya-Wei; Wu, Jing-Yiing; Wu, Meng-Ling; Wu, Kenneth K; Yet, Shaw-Fang; Kuo, Cheng-Chin.
Affiliation
  • Lee GL; Institute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan.
Arterioscler Thromb Vasc Biol ; 32(11): 2751-60, 2012 Nov.
Article in En | MEDLINE | ID: mdl-22995520
Subject(s)
Atherosclerosis/metabolism; Chemotaxis; Cyclic AMP Response Element-Binding Protein/metabolism; Interleukin-6/metabolism; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/metabolism; Toll-Like Receptor 2/metabolism; Animals; Antibodies, Neutralizing/pharmacology; Atherosclerosis/genetics; Atherosclerosis/immunology; Atherosclerosis/pathology; Cell Proliferation; Cell Survival; Cells, Cultured; Chemotaxis/drug effects; Cyclic AMP Response Element-Binding Protein/genetics; Dose-Response Relationship, Drug; Interleukin-6/antagonists & inhibitors; Interleukin-6/genetics; Ligands; Lipopeptides/pharmacology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors; Mitogen-Activated Protein Kinase 3/metabolism; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/immunology; Muscle, Smooth, Vascular/pathology; Myocytes, Smooth Muscle/drug effects; Myocytes, Smooth Muscle/immunology; Myocytes, Smooth Muscle/pathology; Neuropeptides/genetics; Neuropeptides/metabolism; Phosphorylation; Promoter Regions, Genetic; Protein Kinase Inhibitors/pharmacology; RNA Interference; Signal Transduction; Stress Fibers/metabolism; Time Factors; Toll-Like Receptor 2/agonists; Toll-Like Receptor 2/deficiency; Toll-Like Receptor 2/genetics; Transfection; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases/metabolism; rac GTP-Binding Proteins/genetics; rac GTP-Binding Proteins/metabolism; rac1 GTP-Binding Protein

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemotaxis / Interleukin-6 / Cyclic AMP Response Element-Binding Protein / Myocytes, Smooth Muscle / Atherosclerosis / Toll-Like Receptor 2 / Muscle, Smooth, Vascular Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2012 Type: Article Affiliation country: Taiwan

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemotaxis / Interleukin-6 / Cyclic AMP Response Element-Binding Protein / Myocytes, Smooth Muscle / Atherosclerosis / Toll-Like Receptor 2 / Muscle, Smooth, Vascular Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2012 Type: Article Affiliation country: Taiwan