DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.

Kerr, Jeffrey B; Hutt, Karla J; Michalak, Ewa M; Cook, Michele; Vandenberg, Cassandra J; Liew, Seng H; Bouillet, Philippe; Mills, Alea; Scott, Clare L; Findlay, Jock K; Strasser, Andreas

Kerr, Jeffrey B; Hutt, Karla J; Michalak, Ewa M; Cook, Michele; Vandenberg, Cassandra J; Liew, Seng H; Bouillet, Philippe; Mills, Alea; Scott, Clare L; Findlay, Jock K; Strasser, Andreas.

Affiliation

Kerr JB; Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3168, Australia.

Mol Cell ; 48(3): 343-52, 2012 Nov 09.

Article in En | MEDLINE | ID: mdl-23000175

Subject(s)

Apoptosis Regulatory Proteins/genetics; Apoptosis/genetics; DNA Damage; Fertility/genetics; Oocytes/metabolism; Tumor Suppressor Proteins/genetics; Animals; Apoptosis/radiation effects; Apoptosis Regulatory Proteins/metabolism; Female; Gamma Rays; Gene Expression/radiation effects; Immunohistochemistry; In Situ Hybridization; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Oocytes/cytology; Oocytes/radiation effects; Phosphoproteins/genetics; Phosphoproteins/metabolism; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; Trans-Activators/genetics; Trans-Activators/metabolism; Tumor Suppressor Protein p53/deficiency; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / DNA Damage / Apoptosis / Tumor Suppressor Proteins / Apoptosis Regulatory Proteins / Fertility Limits: Animals Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2012 Type: Article Affiliation country: Australia

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