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Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.
Maloney, Patrick R; Khan, Pasha; Hedrick, Michael; Gosalia, Palak; Milewski, Monika; Li, Linda; Roth, Gregory P; Sergienko, Eduard; Suyama, Eigo; Sugarman, Eliot; Nguyen, Kevin; Mehta, Alka; Vasile, Stefan; Su, Ying; Stonich, Derek; Nguyen, Hung; Zeng, Fu-Yue; Novo, Arianna Mangravita; Vicchiarelli, Michael; Diwan, Jena; Chung, Thomas D Y; Smith, Layton H; Pinkerton, Anthony B.
Affiliation
  • Maloney PR; Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL 32827, USA.
Bioorg Med Chem Lett ; 22(21): 6656-60, 2012 Nov 01.
Article in En | MEDLINE | ID: mdl-23010269
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrans / Receptors, G-Protein-Coupled / Drug Discovery / Nitrobenzoates Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrans / Receptors, G-Protein-Coupled / Drug Discovery / Nitrobenzoates Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: United States