Standardization of the teratoma assay for analysis of pluripotency of human ES cells and biosafety of their differentiated progeny.

Gropp, Michal; Shilo, Vitali; Vainer, Gilad; Gov, Miri; Gil, Yaniv; Khaner, Hanita; Matzrafi, Limor; Idelson, Maria; Kopolovic, Juri; Zak, Naomi B; Reubinoff, Benjamin E

Gropp, Michal; Shilo, Vitali; Vainer, Gilad; Gov, Miri; Gil, Yaniv; Khaner, Hanita; Matzrafi, Limor; Idelson, Maria; Kopolovic, Juri; Zak, Naomi B; Reubinoff, Benjamin E.

Affiliation

Gropp M; The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

PLoS One ; 7(9): e45532, 2012.

Article in En | MEDLINE | ID: mdl-23049812

Subject(s)

Biological Assay/standards; Embryonic Stem Cells/pathology; Pluripotent Stem Cells/pathology; Teratoma/pathology; Animals; Biomarkers/metabolism; Cell Count; Cell Differentiation; Collagen/administration & dosage; Drug Combinations; Embryonic Stem Cells/transplantation; Feeder Cells/cytology; Feeder Cells/transplantation; Fibroblasts/cytology; Fibroblasts/transplantation; Humans; Injections, Subcutaneous; Karyotyping; Laminin/administration & dosage; Mice; Mice, Inbred NOD; Mice, SCID; Pluripotent Stem Cells/transplantation; Proteoglycans/administration & dosage; Sensitivity and Specificity; Survival Rate; Teratoma/mortality

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Teratoma / Biological Assay / Pluripotent Stem Cells / Embryonic Stem Cells Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Type: Article Affiliation country: Israel

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