Secretory products from epicardial adipose tissue of patients with type 2 diabetes mellitus induce cardiomyocyte dysfunction.

Greulich, Sabrina; Maxhera, Bujar; Vandenplas, Guy; de Wiza, Daniella Herzfeld; Smiris, Konstantinos; Mueller, Heidi; Heinrichs, Jessica; Blumensatt, Marcel; Cuvelier, Claude; Akhyari, Payam; Ruige, Johannes B; Ouwens, D Margriet; Eckel, Juergen

Greulich, Sabrina; Maxhera, Bujar; Vandenplas, Guy; de Wiza, Daniella Herzfeld; Smiris, Konstantinos; Mueller, Heidi; Heinrichs, Jessica; Blumensatt, Marcel; Cuvelier, Claude; Akhyari, Payam; Ruige, Johannes B; Ouwens, D Margriet; Eckel, Juergen.

Affiliation

Greulich S; Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.

Circulation ; 126(19): 2324-34, 2012 Nov 06.

Article in En | MEDLINE | ID: mdl-23065384

Subject(s)

Activins/pharmacology; Adipose Tissue/metabolism; Angiopoietin-2/pharmacology; Diabetes Mellitus, Type 2/metabolism; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/physiology; Pericardium/metabolism; Activins/metabolism; Adipose Tissue/pathology; Aged; Angiopoietin-2/metabolism; Animals; Biopsy; Calcium/metabolism; Cells, Cultured; Culture Media, Conditioned/pharmacology; Humans; Insulin/metabolism; Male; Models, Animal; Myocytes, Cardiac/pathology; Pericardium/pathology; Rats; Rats, Inbred Lew; Sarcomeres/drug effects; Sarcomeres/metabolism; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism; Signal Transduction/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pericardium / Adipose Tissue / Activins / Myocytes, Cardiac / Angiopoietin-2 / Diabetes Mellitus, Type 2 Type of study: Prognostic_studies Limits: Aged / Animals / Humans / Male Language: En Journal: Circulation Year: 2012 Type: Article Affiliation country: Germany

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