Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.

Shen, Shensi; Niso-Santano, Mireia; Adjemian, Sandy; Takehara, Tetsuo; Malik, Shoaib Ahmad; Minoux, Hervé; Souquere, Sylvie; Mariño, Guillermo; Lachkar, Sylvie; Senovilla, Laura; Galluzzi, Lorenzo; Kepp, Oliver; Pierron, Gérard; Maiuri, Maria Chiara; Hikita, Hayato; Kroemer, Romano; Kroemer, Guido

Shen, Shensi; Niso-Santano, Mireia; Adjemian, Sandy; Takehara, Tetsuo; Malik, Shoaib Ahmad; Minoux, Hervé; Souquere, Sylvie; Mariño, Guillermo; Lachkar, Sylvie; Senovilla, Laura; Galluzzi, Lorenzo; Kepp, Oliver; Pierron, Gérard; Maiuri, Maria Chiara; Hikita, Hayato; Kroemer, Romano; Kroemer, Guido.

Affiliation

Shen S; INSERM, U848, 94805 Villejuif, France.

Mol Cell ; 48(5): 667-80, 2012 Dec 14.

Article in En | MEDLINE | ID: mdl-23084476

Subject(s)

Autophagy; Cytoplasm/enzymology; Eukaryotic Initiation Factor-2/metabolism; STAT3 Transcription Factor/metabolism; eIF-2 Kinase/metabolism; Animals; Autophagy/drug effects; Catalytic Domain; Cell Line, Tumor; Enzyme Activation; Eukaryotic Initiation Factor-2/deficiency; Eukaryotic Initiation Factor-2/genetics; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Palmitic Acid/pharmacology; Phosphorylation; Protein Conformation; Protein Interaction Domains and Motifs; Protein Interaction Mapping; RNA Interference; Recombinant Fusion Proteins/metabolism; STAT3 Transcription Factor/antagonists & inhibitors; STAT3 Transcription Factor/chemistry; STAT3 Transcription Factor/deficiency; STAT3 Transcription Factor/genetics; Signal Transduction; Time Factors; Transfection; eIF-2 Kinase/chemistry; eIF-2 Kinase/genetics; src Homology Domains

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Eukaryotic Initiation Factor-2 / EIF-2 Kinase / Cytoplasm / STAT3 Transcription Factor Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2012 Type: Article Affiliation country: France

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