The high immunogenicity induced by modified sporozoites' malarial peptides depends on their phi (Ï) and psi (ψ) angles.
Biochem Biophys Res Commun
; 429(1-2): 81-6, 2012 Dec 07.
Article
in En
| MEDLINE
| ID: mdl-23142229
ABSTRACT
The importance of CSP- and STARP-derived Ï and ψ dihedral angles in mHABP structure was analysed by (1)H NMR in the search for molecules which can be included as components of a first-line-of-defence Plasmodium falciparum sporozoite multi-epitope vaccine against the most lethal form of human malaria. Most of the aforementioned dihedral angles were left-hand-like polyproline type II (PPII(L)) structures whilst others had right-hand-like α-helix (α(R)), thus allowing mHABPS to fit better into MHCII molecules and thereby form an appropriate pMHCII complex and also establish the H-bonds which stabilise such complex and by this means induce an appropriate immune response. This information has great implications for vaccine development, malaria being one of them.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmodium falciparum
/
Protozoan Proteins
/
Malaria Vaccines
/
Antigens, Protozoan
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2012
Type:
Article
Affiliation country:
Colombia