2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate promotes megakaryocytic differentiation of myeloid leukaemia cells and primary human CD34âº haematopoietic stem cells.

Limb, Jin-Kyung; Song, Doona; Jeon, Mijeong; Han, So-Yeop; Han, Gyoonhee; Jhon, Gil-Ja; Bae, Yun Soo; Kim, Jaesang

2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate promotes megakaryocytic differentiation of myeloid leukaemia cells and primary human CD34âº haematopoietic stem cells.

Limb, Jin-Kyung; Song, Doona; Jeon, Mijeong; Han, So-Yeop; Han, Gyoonhee; Jhon, Gil-Ja; Bae, Yun Soo; Kim, Jaesang.

Affiliation

Limb JK; Division of Life and Pharmaceutical Sciences and Centre for Cell Signalling and Drug Discovery Research, Ewha Womans University, Seoul, Republic of Korea; Department of Chemistry and Division of Nano Sciences, Ewha Womans University, Seoul, Republic of Korea.

J Tissue Eng Regen Med ; 9(4): 435-46, 2015 Apr.

Article in En | MEDLINE | ID: mdl-23166016

Subject(s)

Cell Differentiation/drug effects; Hematopoietic Stem Cells/metabolism; Leukemia, Myeloid/metabolism; MAP Kinase Signaling System/drug effects; Megakaryocytes/metabolism; Organophosphates/pharmacology; Humans; K562 Cells; P-Selectin/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Receptor, PAR-1/metabolism; Receptors, Thrombin/metabolism

Key words

HEL; K562; differentiation; haematopoietic stem cell; megakaryocyte; platelet

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organophosphates / Hematopoietic Stem Cells / Megakaryocytes / Leukemia, Myeloid / Cell Differentiation / MAP Kinase Signaling System Limits: Humans Language: En Journal: J Tissue Eng Regen Med Journal subject: BIOTECNOLOGIA / HISTOLOGIA Year: 2015 Type: Article

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