Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.

Catarzi, Daniela; Colotta, Vittoria; Varano, Flavia; Poli, Daniela; Squarcialupi, Lucia; Filacchioni, Guido; Varani, Katia; Vincenzi, Fabrizio; Borea, Pier Andrea; Dal Ben, Diego; Lambertucci, Catia; Cristalli, Gloria

Catarzi, Daniela; Colotta, Vittoria; Varano, Flavia; Poli, Daniela; Squarcialupi, Lucia; Filacchioni, Guido; Varani, Katia; Vincenzi, Fabrizio; Borea, Pier Andrea; Dal Ben, Diego; Lambertucci, Catia; Cristalli, Gloria.

Affiliation

Catarzi D; Dipartimento di Scienze Farmaceutiche, Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente Attivi, Universita' di Firenze, Polo Scientifico, Via Ugo Schiff 6, 50019 Sesto Fiorentino, FI, Italy. daniela.catarzi@unifi.it

Bioorg Med Chem ; 21(1): 283-94, 2013 Jan 01.

Article in En | MEDLINE | ID: mdl-23171656

Subject(s)

Purinergic P1 Receptor Antagonists/chemistry; Purinergic P1 Receptor Antagonists/pharmacology; Pyrazoles/chemistry; Pyrazoles/pharmacology; Quinazolines/chemistry; Quinazolines/pharmacology; Receptor, Adenosine A3/metabolism; Animals; CHO Cells; Cricetinae; Humans; Molecular Dynamics Simulation; Structure-Activity Relationship

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Quinazolines / Receptor, Adenosine A3 / Purinergic P1 Receptor Antagonists Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: Italy

Fulltext

XML

PubMed Links

Search on Google