IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules.

Orabi, Abrahim I; Luo, Yuhuan; Ahmad, Mahwish U; Shah, Ahsan U; Mannan, Zahir; Wang, Dong; Sarwar, Sheharyar; Muili, Kamaldeen A; Shugrue, Christine; Kolodecik, Thomas R; Singh, Vijay P; Lowe, Mark E; Thrower, Edwin; Chen, Ju; Husain, Sohail Z

Orabi, Abrahim I; Luo, Yuhuan; Ahmad, Mahwish U; Shah, Ahsan U; Mannan, Zahir; Wang, Dong; Sarwar, Sheharyar; Muili, Kamaldeen A; Shugrue, Christine; Kolodecik, Thomas R; Singh, Vijay P; Lowe, Mark E; Thrower, Edwin; Chen, Ju; Husain, Sohail Z.

Affiliation

Orabi AI; Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

PLoS One ; 7(11): e48465, 2012.

Article in En | MEDLINE | ID: mdl-23185258

Subject(s)

Acinar Cells/metabolism; Inositol 1,4,5-Trisphosphate Receptors/deficiency; Pancreas/metabolism; Pancreas/pathology; Secretory Vesicles/metabolism; Acinar Cells/enzymology; Acinar Cells/pathology; Acinar Cells/ultrastructure; Amylases/blood; Amylases/metabolism; Animals; Calcium Signaling; Cell Polarity; Ceruletide/metabolism; Inositol 1,4,5-Trisphosphate Receptors/metabolism; Male; Mice; Pancreas/enzymology; Pancreas/ultrastructure; Secretory Vesicles/ultrastructure

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreas / Secretory Vesicles / Inositol 1,4,5-Trisphosphate Receptors / Acinar Cells Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google