Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.

Suzuki, Kazuyo; Harada, Norio; Yamane, Shunsuke; Nakamura, Yasuhiko; Sasaki, Kazuki; Nasteska, Daniela; Joo, Erina; Shibue, Kimitaka; Harada, Takanari; Hamasaki, Akihiro; Toyoda, Kentaro; Nagashima, Kazuaki; Inagaki, Nobuya

Suzuki, Kazuyo; Harada, Norio; Yamane, Shunsuke; Nakamura, Yasuhiko; Sasaki, Kazuki; Nasteska, Daniela; Joo, Erina; Shibue, Kimitaka; Harada, Takanari; Hamasaki, Akihiro; Toyoda, Kentaro; Nagashima, Kazuaki; Inagaki, Nobuya.

Affiliation

Suzuki K; Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Kyoto 606-8507, Japan.

J Biol Chem ; 288(3): 1929-38, 2013 Jan 18.

Article in En | MEDLINE | ID: mdl-23192339

Subject(s)

Adipose Tissue/metabolism; DNA-Binding Proteins/genetics; Enteroendocrine Cells/metabolism; Gastric Inhibitory Polypeptide/genetics; Obesity/genetics; Transcription Factors/genetics; Adipose Tissue/pathology; Animals; DNA-Binding Proteins/antagonists & inhibitors; DNA-Binding Proteins/metabolism; Diet, High-Fat/adverse effects; Enteroendocrine Cells/pathology; Gastric Inhibitory Polypeptide/metabolism; Gene Expression; Gene Knock-In Techniques; Genes, Reporter; Glucose/metabolism; Green Fluorescent Proteins; Insulin/metabolism; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Mice; Mice, Transgenic; Obesity/etiology; Obesity/metabolism; Obesity/pathology; Oligonucleotide Array Sequence Analysis; Primary Cell Culture; Promoter Regions, Genetic; Protein Binding; RNA, Small Interfering; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors/antagonists & inhibitors; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Gastric Inhibitory Polypeptide / Adipose Tissue / Enteroendocrine Cells / DNA-Binding Proteins / Obesity Type of study: Etiology_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: Japan

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