Aging/drug effects; Aging/physiology; Caloric Restriction; Longevity/drug effects; Longevity/physiology; Sirolimus/pharmacology; Age of Onset; Aging/genetics; Animal Diseases/epidemiology; Animal Diseases/genetics; Animal Diseases/prevention & control; Animals; Biomedical Research; Cardiovascular Diseases/prevention & control; Female; Gene Expression Profiling; Geriatrics/methods; Humans; Longevity/genetics; Macaca mulatta/physiology; Male; Mice; Models, Animal; Neoplasms/prevention & control; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Resveratrol; Sirolimus/adverse effects; Sirolimus/analogs & derivatives; Sirolimus/immunology; Sirtuins/deficiency; Sirtuins/genetics; Sirtuins/metabolism; Somatomedins/genetics; Somatomedins/metabolism; Stilbenes/pharmacology; TOR Serine-Threonine Kinases/metabolism