Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemia.

Zhou, Ting-Fa; Yu, Jin-Gui

Zhou, Ting-Fa; Yu, Jin-Gui.

Affiliation

Zhou TF; Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan, China.

J Surg Res ; 183(1): 304-12, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23236988

Subject(s)

Brain Diseases/etiology; Endotoxemia/complications; Erythropoietin/therapeutic use; Janus Kinase 2/metabolism; STAT3 Transcription Factor/metabolism; Animals; Apoptosis/drug effects; Brain Diseases/metabolism; Brain Diseases/prevention & control; Cecum/surgery; Cell Survival/drug effects; Cognition Disorders/etiology; Cognition Disorders/prevention & control; Disease Models, Animal; Endotoxemia/drug therapy; Endotoxemia/metabolism; Erythropoietin/pharmacology; Humans; Learning Disabilities/etiology; Learning Disabilities/prevention & control; Ligation; Lipopolysaccharides; Male; Memory Disorders/etiology; Memory Disorders/prevention & control; Neurons/drug effects; Rats; Rats, Sprague-Dawley; Recombinant Proteins/pharmacology; Recombinant Proteins/therapeutic use; bcl-2-Associated X Protein/metabolism; bcl-X Protein/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Diseases / Erythropoietin / Endotoxemia / STAT3 Transcription Factor / Janus Kinase 2 Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Surg Res Year: 2013 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google