Peroxiredoxin 1 knockdown potentiates ß-lapachone cytotoxicity through modulation of reactive oxygen species and mitogen-activated protein kinase signals.

He, Tiantian; Banach-Latapy, Agata; Vernis, Laurence; Dardalhon, Michèle; Chanet, Roland; Huang, Meng-Er

He, Tiantian; Banach-Latapy, Agata; Vernis, Laurence; Dardalhon, Michèle; Chanet, Roland; Huang, Meng-Er.

Affiliation

He T; Centre National de la Recherche Scientifique, UMR 3348 Genotoxic Stress and Cancer, Orsay, France.

Carcinogenesis ; 34(4): 760-9, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23239746

Subject(s)

Naphthoquinones/pharmacology; Neoplasms/drug therapy; Peroxiredoxins/genetics; Reactive Oxygen Species/metabolism; Apoptosis/physiology; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases/metabolism; HeLa Cells; Humans; Hydrogen Peroxide/metabolism; JNK Mitogen-Activated Protein Kinases/metabolism; MAP Kinase Signaling System; NAD(P)H Dehydrogenase (Quinone)/metabolism; Neoplasms/metabolism; Peroxiredoxins/metabolism; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases/biosynthesis; Poly(ADP-ribose) Polymerases/metabolism; RNA Interference; RNA, Small Interfering; Reverse Transcriptase Inhibitors/pharmacology; Thioredoxins/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Naphthoquinones / Reactive Oxygen Species / Peroxiredoxins / Neoplasms Limits: Humans Language: En Journal: Carcinogenesis Year: 2013 Type: Article Affiliation country: France

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