ß-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.

Rosenbluh, Joseph; Nijhawan, Deepak; Cox, Andrew G; Li, Xingnan; Neal, James T; Schafer, Eric J; Zack, Travis I; Wang, Xiaoxing; Tsherniak, Aviad; Schinzel, Anna C; Shao, Diane D; Schumacher, Steven E; Weir, Barbara A; Vazquez, Francisca; Cowley, Glenn S; Root, David E; Mesirov, Jill P; Beroukhim, Rameen; Kuo, Calvin J; Goessling, Wolfram; Hahn, William C

Rosenbluh, Joseph; Nijhawan, Deepak; Cox, Andrew G; Li, Xingnan; Neal, James T; Schafer, Eric J; Zack, Travis I; Wang, Xiaoxing; Tsherniak, Aviad; Schinzel, Anna C; Shao, Diane D; Schumacher, Steven E; Weir, Barbara A; Vazquez, Francisca; Cowley, Glenn S; Root, David E; Mesirov, Jill P; Beroukhim, Rameen; Kuo, Calvin J; Goessling, Wolfram; Hahn, William C.

Affiliation

Rosenbluh J; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

Cell ; 151(7): 1457-73, 2012 Dec 21.

Article in En | MEDLINE | ID: mdl-23245941

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Cell Transformation, Neoplastic; Colonic Neoplasms/metabolism; Phosphoproteins/metabolism; T-Box Domain Proteins/metabolism; beta Catenin/metabolism; Animals; Cell Line, Tumor; Colon/embryology; Colon/metabolism; Colonic Neoplasms/pathology; Humans; Inhibitor of Apoptosis Proteins/genetics; Mice; Mice, Nude; Proto-Oncogene Proteins c-yes/antagonists & inhibitors; Proto-Oncogene Proteins c-yes/metabolism; Survivin; Transcription Factors; Transcription, Genetic; YAP-Signaling Proteins; Zebrafish/embryology; bcl-X Protein/genetics; src-Family Kinases/antagonists & inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Cell Transformation, Neoplastic / Colonic Neoplasms / T-Box Domain Proteins / Adaptor Proteins, Signal Transducing / Beta Catenin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Year: 2012 Type: Article Affiliation country: United States

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