Respiratory morbidity at follow-up of small-for-gestational-age infants born very prematurely.
Pediatr Res
; 73(4 Pt 1): 457-63, 2013 Apr.
Article
in En
| MEDLINE
| ID: mdl-23269120
ABSTRACT
BACKGROUND:
The aim of this study was to determine whether small-for-gestational-age (SGA) infants born very prematurely had increased respiratory morbidity in the neonatal period and at follow-up.METHODS:
Data were examined from infants recruited into the United Kingdom Oscillation Study (UKOS). Of the 797 infants who were born at <29 wk of gestational age, 174 infants were SGA. Overall, 92% were exposed to antenatal corticosteroids and 97% received surfactant; follow-up data at 22-28 mo were available for 367 infants.RESULTS:
After adjustment for gestational age and sex, SGA infants had higher rates of supplementary oxygen dependency at 36 wk postmenstrual age (odds ratio (OR) 3.23; 95% confidence interval 2.03, 5.13), pulmonary hemorrhage (OR 3.07; 95% CI 1.82, 5.18), death (OR 3.32; 95% CI 2.13, 5.17), and postnatal corticosteroid requirement (OR 2.09; 95% CI 1.35, 3.23). After adjustment for infant and respiratory morbidity risk factors, a lower mean birth weight z-score was associated with a higher prevalence of respiratory admissions (OR 1.40; 95% CI 1.03, 1.88 for 1 SD change in z-score), cough (OR 1.28; 95% CI 1.00, 1.65), and use of chest medicines (OR 1.32; 95% CI 1.01, 1.73).CONCLUSION:
SGA infants who were born very prematurely, despite routine use of antenatal corticosteroids and postnatal surfactant, had increased respiratory morbidity at follow-up, which was not due to poor neonatal outcome.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiration
/
Respiratory Tract Diseases
/
Infant, Small for Gestational Age
/
Infant, Extremely Premature
/
Lung
Type of study:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Country/Region as subject:
Europa
Language:
En
Journal:
Pediatr Res
Year:
2013
Type:
Article
Affiliation country:
United kingdom