Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity.

Layton, Meredith J; Saad, Mirette; Church, Nicole L; Pearson, Richard B; Mitchell, Christina A; Phillips, Wayne A

Layton, Meredith J; Saad, Mirette; Church, Nicole L; Pearson, Richard B; Mitchell, Christina A; Phillips, Wayne A.

Affiliation

Layton MJ; The Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.

BMC Biochem ; 13: 30, 2012 Dec 27.

Article in En | MEDLINE | ID: mdl-23270540

Subject(s)

Phosphatidylinositol 3-Kinases/metabolism; Serine/metabolism; Class Ia Phosphatidylinositol 3-Kinase/chemistry; Class Ia Phosphatidylinositol 3-Kinase/genetics; Class Ia Phosphatidylinositol 3-Kinase/metabolism; Humans; Kinetics; Mutation; Neoplasms/enzymology; Phosphatidylinositol 3-Kinases/chemistry; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositols/metabolism; Phosphorylation; Recombinant Proteins/biosynthesis; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / Phosphatidylinositol 3-Kinases Type of study: Risk_factors_studies Limits: Humans Language: En Journal: BMC Biochem Journal subject: BIOQUIMICA Year: 2012 Type: Article Affiliation country: Australia

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