Antagonism of purinergic signalling improves recovery from traumatic brain injury.

Choo, Anthony M; Miller, William J; Chen, Yung-Chia; Nibley, Philip; Patel, Tapan P; Goletiani, Cezar; Morrison, Barclay; Kutzing, Melinda K; Firestein, Bonnie L; Sul, Jai-Yoon; Haydon, Philip G; Meaney, David F

Choo, Anthony M; Miller, William J; Chen, Yung-Chia; Nibley, Philip; Patel, Tapan P; Goletiani, Cezar; Morrison, Barclay; Kutzing, Melinda K; Firestein, Bonnie L; Sul, Jai-Yoon; Haydon, Philip G; Meaney, David F.

Affiliation

Choo AM; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

Brain ; 136(Pt 1): 65-80, 2013 Jan.

Article in En | MEDLINE | ID: mdl-23293266

Subject(s)

Adenosine Diphosphate/analogs & derivatives; Astrocytes/drug effects; Brain Injuries/drug therapy; Purinergic P2Y Receptor Antagonists/pharmacology; Recovery of Function/drug effects; Signal Transduction/drug effects; Adenosine Diphosphate/pharmacology; Adenosine Diphosphate/therapeutic use; Animals; Astrocytes/metabolism; Brain Injuries/metabolism; Calcium/metabolism; Cells, Cultured; Cerebral Cortex/drug effects; Cerebral Cortex/injuries; Cerebral Cortex/metabolism; Humans; Maze Learning/drug effects; Mice; Neurons/drug effects; Neurons/metabolism; Purinergic P2Y Receptor Antagonists/therapeutic use; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Injuries / Signal Transduction / Adenosine Diphosphate / Astrocytes / Recovery of Function / Purinergic P2Y Receptor Antagonists Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Brain Year: 2013 Type: Article Affiliation country: United States

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