In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling.

Khoo, Peytee; Allan, Kirsten; Willoughby, Lee; Brumby, Anthony M; Richardson, Helena E

Khoo, Peytee; Allan, Kirsten; Willoughby, Lee; Brumby, Anthony M; Richardson, Helena E.

Affiliation

Khoo P; Cell Cycle and Development Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.

Dis Model Mech ; 6(3): 661-78, 2013 May.

Article in En | MEDLINE | ID: mdl-23324326

Subject(s)

Cell Transformation, Neoplastic/pathology; Drosophila Proteins/metabolism; Drosophila melanogaster/metabolism; Myosin Type II/metabolism; Signal Transduction; ras Proteins/metabolism; rho GTP-Binding Proteins/metabolism; Animals; Apoptosis; Arthropod Antennae/growth & development; Cell Cycle Proteins; Cell Differentiation; Cell Shape; Cell Transformation, Neoplastic/metabolism; Clone Cells; Drosophila melanogaster/enzymology; Enzyme Activation; Gene Knockdown Techniques; Humans; JNK Mitogen-Activated Protein Kinases/metabolism; Larva/metabolism; MAP Kinase Signaling System; Models, Biological; Proto-Oncogene Proteins c-raf/metabolism; Pupa/metabolism; Up-Regulation; rac GTP-Binding Proteins/metabolism; rho-Associated Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cell Transformation, Neoplastic / Ras Proteins / Rho GTP-Binding Proteins / Myosin Type II / Drosophila Proteins / Drosophila melanogaster Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Dis Model Mech Journal subject: MEDICINA Year: 2013 Type: Article Affiliation country: Australia

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