Adenovirus expressing both thymidine kinase and soluble PD1 enhances antitumor immunity by strengthening CD8 T-cell response.

Shin, Seung-Pil; Seo, Hye-Hyun; Shin, Jae-Hun; Park, Hyung-Bae; Lim, Dong-Pyo; Eom, Hyeon-Seok; Bae, Yong-Soo; Kim, In-Hoo; Choi, Kyungho; Lee, Sang-Jin

Shin, Seung-Pil; Seo, Hye-Hyun; Shin, Jae-Hun; Park, Hyung-Bae; Lim, Dong-Pyo; Eom, Hyeon-Seok; Bae, Yong-Soo; Kim, In-Hoo; Choi, Kyungho; Lee, Sang-Jin.

Affiliation

Shin SP; Genitourinary Cancer Branch, Research Institute National Cancer Center, Gyeonggi-do, Korea.

Mol Ther ; 21(3): 688-95, 2013 Mar.

Article in En | MEDLINE | ID: mdl-23337984

Subject(s)

B7-H1 Antigen/genetics; CD8-Positive T-Lymphocytes/immunology; Cancer Vaccines/therapeutic use; Genetic Vectors; Thymidine Kinase/genetics; Adenoviridae/genetics; Animals; Antigens, Neoplasm/genetics; Antigens, Neoplasm/immunology; Antineoplastic Agents/pharmacology; B7-H1 Antigen/metabolism; Cancer Vaccines/immunology; Cell Line, Tumor; Dendritic Cells/immunology; Dendritic Cells/metabolism; Female; Immunity, Cellular/genetics; Immunity, Cellular/immunology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; T-Lymphocytes, Cytotoxic/immunology; Telomerase/genetics; Telomerase/metabolism; Thymidine Kinase/metabolism; Trans-Splicing

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymidine Kinase / CD8-Positive T-Lymphocytes / Cancer Vaccines / B7-H1 Antigen / Genetic Vectors Limits: Animals Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2013 Type: Article

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