The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBP&#945; and differentiation in MLL-AF9 leukemia.

Thiel, Austin T; Feng, Zijie; Pant, Dhruv K; Chodosh, Lewis A; Hua, Xianxin

The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.

Thiel, Austin T; Feng, Zijie; Pant, Dhruv K; Chodosh, Lewis A; Hua, Xianxin.

Affiliation

Thiel AT; Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, the University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.

Haematologica ; 98(6): 918-27, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23349306

Subject(s)

CCAAT-Enhancer-Binding Protein-alpha/metabolism; Leukemia/genetics; Leukemia/metabolism; Myeloid-Lymphoid Leukemia Protein/genetics; Oncogene Proteins, Fusion/genetics; Polycomb Repressive Complex 2/metabolism; Proto-Oncogene Proteins/metabolism; Animals; Cell Differentiation/genetics; Cell Line; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Leukemic; Gene Knockdown Techniques; Genotype; Humans; Mice; Myeloid-Lymphoid Leukemia Protein/metabolism; Oncogene Proteins, Fusion/metabolism; Protein Binding; Proto-Oncogene Proteins/chemistry; Proto-Oncogene Proteins/genetics; Transcriptional Activation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia / Oncogene Proteins, Fusion / Proto-Oncogene Proteins / CCAAT-Enhancer-Binding Protein-alpha / Myeloid-Lymphoid Leukemia Protein / Polycomb Repressive Complex 2 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Haematologica Year: 2013 Type: Article Affiliation country: United States

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