HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.

Wu, Bainan; Zhang, Ziming; Noberini, Roberta; Barile, Elisa; Giulianotti, Marc; Pinilla, Clemencia; Houghten, Richard A; Pasquale, Elena B; Pellecchia, Maurizio

Wu, Bainan; Zhang, Ziming; Noberini, Roberta; Barile, Elisa; Giulianotti, Marc; Pinilla, Clemencia; Houghten, Richard A; Pasquale, Elena B; Pellecchia, Maurizio.

Affiliation

Wu B; Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Chem Biol ; 20(1): 19-33, 2013 Jan 24.

Article in En | MEDLINE | ID: mdl-23352136

Subject(s)

Combinatorial Chemistry Techniques/methods; Drug Design; Magnetic Resonance Spectroscopy/methods; Receptor, EphA4/metabolism; Small Molecule Libraries/chemistry; Small Molecule Libraries/pharmacology; High-Throughput Screening Assays/methods; Humans; Ligands; Models, Molecular; Protein Structure, Tertiary; Receptor, EphA4/chemistry; Structure-Activity Relationship; X-Linked Inhibitor of Apoptosis Protein/chemistry; X-Linked Inhibitor of Apoptosis Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Magnetic Resonance Spectroscopy / Drug Design / Combinatorial Chemistry Techniques / Receptor, EphA4 / Small Molecule Libraries Limits: Humans Language: En Journal: Chem Biol Journal subject: BIOLOGIA / BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: United States

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