Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats.

Yamazaki, Makoto; Miyake, Manami; Sato, Hiroko; Masutomi, Naoya; Tsutsui, Naohisa; Adam, Klaus-Peter; Alexander, Danny C; Lawton, Kay A; Milburn, Michael V; Ryals, John A; Wulff, Jacob E; Guo, Lining

Yamazaki, Makoto; Miyake, Manami; Sato, Hiroko; Masutomi, Naoya; Tsutsui, Naohisa; Adam, Klaus-Peter; Alexander, Danny C; Lawton, Kay A; Milburn, Michael V; Ryals, John A; Wulff, Jacob E; Guo, Lining.

Affiliation

Yamazaki M; Mitsubishi Tanabe Pharma Corporation, Kisarazu, Chiba, Japan.

Toxicol Appl Pharmacol ; 268(1): 79-89, 2013 Apr 01.

Article in En | MEDLINE | ID: mdl-23360887

Subject(s)

Bile Acids and Salts/metabolism; Chemical and Drug Induced Liver Injury/metabolism; Oxidative Stress/physiology; Toxins, Biological/toxicity; Animals; Bile Acids and Salts/blood; Bile Acids and Salts/urine; Biomarkers/blood; Biomarkers/metabolism; Biomarkers/urine; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hepatocytes/metabolism; Male; Metabolomics/methods; Random Allocation; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Toxins, Biological/administration & dosage

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toxins, Biological / Bile Acids and Salts / Oxidative Stress / Chemical and Drug Induced Liver Injury Type of study: Etiology_studies Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2013 Type: Article Affiliation country: Japan

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