Aftins increase amyloid-ß42, lower amyloid-ß38, and do not alter amyloid-ß40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?

Hochard, Arnaud; Oumata, Nassima; Bettayeb, Karima; Gloulou, Olfa; Fant, Xavier; Durieu, Emilie; Buron, Nelly; Porceddu, Mathieu; Borgne-Sanchez, Annie; Galons, Hervé; Flajolet, Marc; Meijer, Laurent

Hochard, Arnaud; Oumata, Nassima; Bettayeb, Karima; Gloulou, Olfa; Fant, Xavier; Durieu, Emilie; Buron, Nelly; Porceddu, Mathieu; Borgne-Sanchez, Annie; Galons, Hervé; Flajolet, Marc; Meijer, Laurent.

Affiliation

Hochard A; ManRos Therapeutics, Centre de Perharidy, Roscoff, Bretagne, France.

J Alzheimers Dis ; 35(1): 107-20, 2013.

Article in En | MEDLINE | ID: mdl-23364140

Subject(s)

Adenine/analogs & derivatives; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Models, Chemical; Peptide Fragments/metabolism; Adenine/pharmacology; Adenine/toxicity; Cell Line; Cell Survival/drug effects; Cell Survival/physiology; Dose-Response Relationship, Drug; Extracellular Space/drug effects; Extracellular Space/metabolism; Humans

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Adenine / Amyloid beta-Peptides / Alzheimer Disease / Models, Chemical Limits: Humans Language: En Journal: J Alzheimers Dis Journal subject: GERIATRIA / NEUROLOGIA Year: 2013 Type: Article Affiliation country: France

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